Characterisation of COPD heterogeneity in the ECLIPSE cohort
By Alvar Agusti, P. Calverley, Bartolome Celli, H. Coxson, L. Edwards, D. Lomas, W. Macnee, B. Miller, S. Rennard, E. Silverman and 4 more. Respiratory Research, 2010
1,244 citations recorded by the source corpus.
BackgroundChronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE).MethodsWe studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography.ResultsCOPD patients were slightly older than controls and had more pack years of smoking than smokers with normal lung function. Co-morbidities were more prevalent in COPD patients than in controls, and occurred to the same extent irrespective of the GOLD stage. The severity of airflow limitation in COPD patients was poorly related to the degree of breathlessness, health status, presence of co-morbidity, exercise capacity and number of exacerbations reported in the year before the study. The distribution of these variables within each GOLD stage was wide. Even in subjects with severe airflow obstruction, a substantial proportion did not report symptoms, exacerbations or exercise limitation. The amount of emphysema increased with GOLD severity. The prevalence of bronchiectasis was low (4%) but also increased with GOLD stage. Some gender differences were also identified.ConclusionsThe clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.
Subfields: Pulmonary and Respiratory Medicine, Sociology and Political Science
View Paper: https://www.semanticscholar.org/paper/40fa41938c0c969c1ab6219b857fcd884f7a804b
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Citations in the corpus
- Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution (2023, positive): “Большой объем данных был собран при обследова нии пациентов с помощью спирометрической класси фикации GOLD [131, 512].”
- Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. (2012, background): “The risk conferred by peptic ulcer disease is very interesting in light of the findings reported by the ECLIPSE (41) investigators, where one of the predictors of frequent COPD exacerbations was the presence of gastroesophageal reflux.”
- Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype (2012, methodology): “We recruited into the ECLIPSE study 2164 patients with COPD, 337 smoking and 245 non-smoking controls [15].”
- Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. (2013, background): “Although defined by the presence of chronic airflow limitation, COPD is nowadays considered a complex, heterogeneous, and multicomponent condition (1).”
- Dynamic data during hypotensive episode improves mortality predictions among patients with sepsis and hypotension (2013, background): “• Laboratory and clinical values: Patients’ laboratory results during the 24 hours before the onset and after the end of the hypotensive event: PaO 2 (mm Hg), Fio 2 (mm Hg/torr), Glasgow Coma Scale (GCS) (19), temperature (°C), arterial pH (units), bicarbonate (mEq/L), blood urea nitrogen (BUN, mg/d”