Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

By Duncan T. Odom, N. Zizlsperger, D. B. Gordon, George W. Bell, Nicola J. Rinaldi, Heather L. Murray, T. Volkert, Jörg Schreiber, P. A. Rolfe, David K. Gifford and 3 more. Science, 2004

1,414 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/4e78bcb16f3549eae0df26ce1a5fa8adcfeaa8d6

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Citations in the corpus

11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. (2013, background): “In contrast, although HNF4 occupies the HSD11B1 promoter in human hepatocytes (532), any function is unclear.”
Control of developmental regulators by Polycomb in human embryonic stem cells. (2006, methodology): “Labeled DNA was hybridized to self-printed arrays and analyzed as described previously (Odom et al., 2004).”
Common variants at 30 loci contribute to polygenic dyslipidemia (2008, background): “Both genes encode hepatic nuclear transcription factors that regulate numerous target genes involved in lipoprotein metabolism, including apolipoproteins, cholesterol synthesis enzymes and bile acid transporter”
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities (2010, background): “…cell type tend to colocalize on a genome-wide scale (Chen et al., 2008; MacArthur et al., 2009), and (2) the same factor in different cell types or at different stages of development exhibits different genome-wide binding patterns (Lupien et al., 2008; Odom et al., 2004; Sandmann et al., 2006).”
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties (2009, positive): “HNF4A is a liver-enriched transcription factor controlling the differentiation-dependent gene expression in developing and adult livers (Odom et al., 2004).”
CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing (2009, methodology): “The ChIP-chip experiment described here was adapted from previous studies (Odom et al., 2004; Scacheri et al., 2006).”
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. (2005, background): “Most previous ChIP-microarray studies have focused primarily on promoter regions (Odom et al., 2004) or CpG islands, which represent promoter-rich sequences (Weinmann et al., 2002).”
Integrative analysis of the cancer transcriptome (2005, background): “New technologies such as chromatin immunoprecipitation coupled with promoter microarrays (ChIP-chip) allow for genome-wide identification of transcription factor–binding site”
Incomplete DNA methylation underlies a transcriptional memory of the somatic cell in human iPS cells (2011, neutral): “Similarly, the hepatocyte nuclear factor (HNF) transcription factors and their target genes highly expressed in hepatocyte”