The changing epidemiology of Staphylococcus aureus?

By Henry F. Chambers. Emerging Infectious Diseases, 2001

1,728 citations recorded by the source corpus.

Strains of methicillin-resistant Staphylococcus aureus (MRSA), which had been largely confined to hospitals and long-term care facilities, are emerging in the community. The changing epidemiology of MRSA bears striking similarity to the emergence of penicillinase-mediated resistance in S. aureus decades ago. Even though the origin (hospital or the community) of the emerging MRSA strains is not known, the prevalence of these strains in the community seems likely to increase substantially.

Subfields: Clinical Biochemistry, Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/4e3405d32c6cda51be3875b9c55ef72a57e5b6a5

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Citations in the corpus

Community-acquired methicillin-resistant Staphylococcus aureus: a meta-analysis of prevalence and risk factors. (2003, background): “Initially, these resistant strains were associated with nosocomial infections, but dissemination into the community subsequently followed, seemingly at a time when the rate of penicillin resistance among hospital patients with staphylococcal infections approached 50% (figure 2) [68].”
Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? (2006, neutral): “leading cause of hospital-acquired infections [2].”
The molecular evolution of methicillin-resistant Staphylococcus aureus. (2007, background): “The prevalence of CA-MRSA is currently low worldwide, but appears to be increasing [91,95].”
Hospitalizations and Deaths Caused by Methicillin-Resistant Staphylococcus aureus, United States, 1999–2005 (2007, positive): “Penicillin resistance was initially confi ned to a small number of hospitalized patients, but resistance spread as use of penicillin increased, fi rst to other hospitals and then into the community (5).”
Mechanisms of antimicrobial resistance in bacteria. (2006, background): “spontaneous mutations may cause resistance by (1) altering the target protein to which the antibacterial agent binds by modifying or eliminating the binding site (e.g., change in penicillin-binding protein 2b in pneumococci, which results in penicillin resistance), (2) upregulating the production of”
Community-Associated Methicillin-Resistant Staphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic (2010, background): “If the emergence of MRSA is following this pattern (148), the percentage of communityassociated S.”
Staphylococcus epidermidis – the “accidental” pathogen (2009, background): “may have had an enormous impact on public health: it created a strain with both methicillin resistance, at no cost to fitness, and exceptional virulence, which was the molecular basis behind the epidemic caused by CA-MRS”
Antimicrobial resistance: the example of Staphylococcus aureus. (2003, background): “This pattern of resistance, first emerging in hospitals and then spreading to the community, is now a well-established pattern that recurs with each new wave of antimicrobial resistance (13).”
The evolution of Staphylococcus aureus. (2008, background): “In general, CA-MRSA is more virulent compared to HA-MRSA due the presence of various virulence factors (Chambers, 2001; Etienne, 2005).”
Epidemiology of methicillin-resistant Staphylococcus aureus. (2008, background): “Community-associated MRSA infections were initially described in children with bloodstream infections and no prior health care exposure [6] and have been increasingly reported as the cause of skin infections and abscesses among previously healthy adults and as the cause of bloodstream infections amo”