Stable-isotope dimethyl labeling for quantitative proteomics.

By J. Hsu, Sheng‐yu Huang, N. Chow, Shu-Hui Chen. Analytical Chemistry, 2003

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Decoding signalling networks by mass spectrometry-based proteomics (2010, background): “For example, labelling by heavy or light dimethyl group”
Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics (2009, methodology): “The protocols presented here use three differential stable isotopes and are based on a method described earlier by Hsu et al”
Multidimensional proteomics for cell biology (2015, methodology): “…19 , N-labelling 20 and NeuCode SILAC 21 ), or stable-isotope labelling using chemical tags that are covalently attached in vitro (dimethyl-labelling 22,23 , tande m mass tags (TMTs) 24 and isobaric tags for relative and absolute quantification (iTRAQ) 25 (see Supplementary information S1 (box)).”