Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.

By J. Wohlschlegel, B. Dwyer, S. Dhar, Christin Cvetic, Johannes C. Walter, Anindya Dutta. Science, 2000

704 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4dc57dbb4ca56d075d1a0072f3f64d90088ee37d

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In Cell Biology

1. Y. Kubota
2. H. Takisawa
3. Johannes C. Walter

In Molecular Biology

1. Y. Kubota
2. H. Takisawa
3. W. Michael
4. Johannes C. Walter

Citations in the corpus

• The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication (2002, methodology): “To ask if Xmus101 chromatin binding is dependent upon an intact pre-RC once nuclear formation occurs, we assessed Xmus101 chromatin-association in extracts treated with geminin, an inhibitor of the Cdt1 protein (Wohlschlegel et al., 2000; Tada et al., 2001).”
• The N-Terminal Noncatalytic Region of Xenopus RecQ4 Is Required for Chromatin Binding of DNA Polymerase α in the Initiation of DNA Replication (2006, background): “We further found that RecQ4 was bound to chromatin even though the formation of pre-RC was prevented by the addition of geminin (“ geminin”), an inhibitor of Cdt1 (31, 36), to the extracts.”