Nonproteolytic functions of ubiquitin in cell signaling.

By Zhijian J. Chen, Lijun Sun. Molecules and Cells, 2009

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mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6 (2013, methodology): “(d) HEK293 cells were co-transfected with vectors encoding AMBRA1 together with ULK1–Myc FL (full length) or its deletion mutants encoding the kinase and the proline-rich domains (1829–1,051), and the ULK1 carboxy-terminal domain (11-828).”
The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “With the deepening of research, scientists have realized that K48-type polyubiquitination is only the tip of the ubiquitination iceberg.(23,38,39) To date, eight types of polyubiquitin linkages have been identified (K6, K11, K27, K29, K33, K48, K63 and Met1) with specific functions.”
p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation (2016, positive): “A common mechanism involves ubiquitin or polyubiquitin chains recruiting ubiquitin receptors to perform biological functions [37].”
A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles (2011, background): “tion sites, (4) it can be easily applied to map ubiquitylation”