Pivoting the Plant Immune System from Dissection to Deployment

By Jeffery L. Dangl, D. Horvath, B. Staskawicz. Science, 2013

971 citations recorded by the source corpus.

Diverse and rapidly evolving pathogens cause plant diseases and epidemics that threaten crop yield and food security around the world. Research over the last 25 years has led to an increasingly clear conceptual understanding of the molecular components of the plant immune system. Combined with ever-cheaper DNA-sequencing technology and the rich diversity of germ plasm manipulated for over a century by plant breeders, we now have the means to begin development of durable (long-lasting) disease resistance beyond the limits imposed by conventional breeding and in a manner that will replace costly and unsustainable chemical controls.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/4d98edd4766af80fb086305467d243ec7291fa2c

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In Plant Science

1. Yang Bai
2. R. Ennos
3. K. Narisawa
4. K. Peay
5. B. Staskawicz
6. E. Kiers
7. R. Sniezko
8. Y. Onoda

Citations in the corpus

• Host Manipulation by Parasites: Cases, Patterns, and Remaining Doubts (2016, neutral): “…metabolism (Heil and Baldwin, 2002; Scheideler et al., 2002), the re-allocation of nutrients and the de novo synthesis of an extremely diverse array of resistance-related structures, secondary metabolites, peptides and proteins (Karban and Baldwin, 1997; Jones and Dangl, 2006; Dangl et al., 2013).”
• CRISPR-Cas9 mediated mutagenesis of a DMR6 ortholog in tomato confers broad-spectrum disease resistance (2016, background): “Although very promising, resistance based on the deployment of a single R gene can be rapidly overcome by the pathogen due to the emergence of resistant strains (Dangl et al., 2013).”
• Core microbiomes for sustainable agroecosystems (2018, background): “Analogous approaches for crop plants 7 would involve developing bulk soil transplants or extracted soil microbiome cocktails using centrifuge-based techniques, whose application to soybean has successfully allowed us to enrich symbiont cells from healthy plant tissue 92,93 (Fig.”
• Genetic Resistance to Fusiform Rust in Southern Pines and White Pine Blister Rust in White Pines—A Contrasting Tale of Two Rust Pathosystems—Current Status and Future Prospects (2014, background): “ensure healthier forests in the future [18,19].”
• Resilience of forests to pathogens: An evolutionary ecology perspective (2015, background): “They relyon the tree recognizing the presence of a pathogen and triggering an effective defence response in the appropriate local area of tissue (Eyles et al., 2010; Dangl et al., 2013; Kovalchuk et al., 2013).”