p53 Dynamics Control Cell Fate

By Jeremy E. Purvis, Kyle W. Karhohs, Caroline S. Mock, Eric Batchelor, A. Loewer, Galit Lahav. Science, 2012

742 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/4d982d2feadc9d362c632d777d36277add7eb0e8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Jeremy E. Purvis
2. Jiandong Chen
3. Galit Lahav

In Oncology

1. Jeremy E. Purvis
2. Jiandong Chen
3. Galit Lahav

Citations in the corpus

• The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. (2016, background): “For example, the induction of p21 and Gadd45 by p53 peaked 2–6 h after irradiation, whereas Bax induction peaked after 12–24 h (Purvis et al. 2012).”
• Senescence and apoptosis: dueling or complementary cell fates? (2014, neutral): “5–5 Gy—usually induce a transient rise in p53 levels [60], leading to a transient cell cycle arrest followed by recovery [61].”
• Encoding and Decoding Cellular Information through Signaling Dynamics (2013, positive): “This mechanism would explain the accelerated expression of senescence genes under sustained p53 signaling (Purvis et al., 2012).”