Disruption of two novel genes by a translocation co-segregating with schizophrenia.

By J. Millar, Julie C. Wilson-Annan, S. Anderson, S. Christie, Martin S. Taylor, C. Semple, R. S. Devon, D. S. Clair, W. Muir, D. Blackwood and 1 more. Human Molecular Genetics, 2000

1,339 citations recorded by the source corpus.

Subfields: Molecular Biology

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Citations in the corpus

Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. (2011, background): “…MACROD2 (Anney et al., 2010), CDH9 and CDH10 (Wang et al., 2009), the MET oncogene (Campbell et al., 2006), EN2 (Gharani et al., 2004), and selected schizophrenia loci (ISC, 2008; McCarthy et al., 2009; Millar et al., 2000; Stefansson et al., 2008; Walsh et al., 2008; Xu et al., 2008) (Table 3).”
Trekking across the brain: the journey of neuronal migration. (2007, neutral): “Disc-1 Schizophrenia 1q42.1 Schizophrenia Kamiya et al., 2005; Millar et al., 2000”
Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. (2007, background): “Implications for Mental Disorders disc1 was initially identified as a gene disrupted by a balanced translocation on chromosome 1q42 that segregates with schizophrenia, bipolar disorder, and recurrent major depression in a large Scottish family (Blackwood et al., 2001; Millar et al., 2000).”
Stress signalling pathways that impair prefrontal cortex structure and function (2009, neutral): “Loss-of-function translocations in DISC1 are associated with high rates of mental illnes”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, positive): “DISC1 was originally identified at the breakpoint of a balanced (1;11) (q42;q14) chromosome translocation that cosegregates with schizophrenia, bipolar disorder, and recurrent major depression in a large Scottish family (Blackwood et al., 2001; Millar et al., 2000).”
Microduplications of 16p11.2 are Associated with Schizophrenia (2009, background): “7 ) and a balanced translocation disrupting the gene DISC1 (ref”
Interneuron dysfunction in psychiatric disorders (2012, background): “This gene was initially linked to neuropsychiatric disease through the discovery that a large chromosomal translocation in the middle of its open reading frame segregated with schizophrenia, bipolar disorder and depression in a large Scottish famil”
Disrupted-in-Schizophrenia-1 (2008, background): “The main gene was labeled as Disrupted-in-Schizophrenia-1 (DISC1), and a second, partly nested gene existed on the opposite DNA strand running antisense (probably an RNA coding gene, DISC2) [12,13].”
The genetics of schizophrenia and bipolar disorder: dissecting psychosis (2005, background): “The DISC1 locus at 1q42 receives linkage support in both schizophrenia 87–89 and bipolar disorder 156 and, although it has been named ‘‘Disrupted in Schizophrenia’’, the family in which the translocation was observed contained cases of both psychosis and mood disorder; indeed the formal linkage…”
Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies (2009, background): “In fact, evidence that schizophrenia and MDD share common genetic background is found in the original DISC1-gene study (DISC1 1⁄4 Disrupted in Schizophrenia-1 family)[Millar et al., 2000].”