Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo.

By M. D. Griffin, W. Lutz, V. A. Phan, L. A. Bachman, D. J. McKean, R. Kumar. Proceedings of the National Academy of Sciences of the United States of America, 2001

657 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/4cfdec27ba8a99e309380838767e66432d46cd64

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Citations in the corpus

Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “A study focusing on the phenotype of DCs in normocalcemic VDR null mice found some abnormalities in DCs from skindraining lymph nodes (423).”
Overview of general physiologic features and functions of vitamin D. (2004, background): “Alternative ideas have also been put forth, such as suppression of the dendritic cells that present antigens to the T cells ( 54 ).”
Noncalcemic actions of vitamin D receptor ligands. (2005, background): “Under differentiation conditions in the presence of GM-CSF and IL-4 from purified human CD14 monocytes, 1,25-(OH)2D3 completely inhibited DC differentiation with low-level expression of IL-12 and maturation markers (144, 145).”
Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. (2005, unknown): “At least in the case of dendritic cells, this may act as part of a feedback control mechanism to limit an overactive immune response as 1,25(OH)2D3 actively suppresses further dendritic cell development provided the cells express VDR (Griffin et al., 2001; Hewison et al., 2003, 2004).”
1,25-dihydroxyvitamin D3 and interleukin-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3 (2009, background): “DCs treated with 1,25(OH)2D3 remain in an immature state with reduced expression of costimulatory molecules and IL-12 (23, 25, 27, 28).”
Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. (2016, background): “The altered dendritic cells have a reduced expression of class II MHC, costimulatory molecules (CD40, CD80, CD86) and a changed IL12/IL10 ratio (145, 174, 356).”
Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1 (2001, background): “DC modulation by 1,25(OH)2D3 has recently been shown to require a vitamin D receptor-dependent pathway that could promote a persistent inhibition of DC maturation in vitro and in vivo (41).”