Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication

By P. Pisitkun, J. Deane, M. Difilippantonio, Tatyana N. Tarasenko, A. Satterthwaite, S. Bolland. Science, 2006

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Murine Models of Systemic Lupus Erythematosus (2011, background): “It is now known that Yaa is due to a translocation of the telomeric end of the X chromosome to the Y chromosome, resulting in the duplication of at least 16 genes and a ∼2fold expression in many of these genes [54, 55].”
Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “…BXSB background , is due to a translocation of the TLR7 gene into the Y chromosome, explaining the predominantly male predisposition to disease in this particular model (Pisitkun et al., 2006; Subramanian et al., 2006), which is at striking difference with the 9:1 female to male ratio in human SLE.”
Pattern recognition receptors and inflammation. (2010, background): “Duplication of the Tlr7 gene accounts for the autoimmune phenotypes associated with Y chromosome-linked autoimmune accelerator (Yaa) mice (Pisitkun et al., 2006; Subramanian et al., 2006).”
Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, positive): “TLR7 and TLR9 are important for autoantibody production in a murine model of lupus (Christensen et al., 2006), and a spontaneous gene duplication of murine TLR7 predisposes to autoimmunity (Pisitkun et al., 2006; Subramanian et al., 2006).”