THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
By Stephen P. H. Alexander, Arthur Christopoulos, A. Davenport, E. Kelly, A. Mathie, John A. Peters, E. Veale, J. Armstrong, E. Faccenda, S. Harding and 4 more. 2019
647 citations recorded by the source corpus.
The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands ( www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.14748 . G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2019, and supersedes data presented in the 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
Subfields: Biochemistry, Molecular Biology
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In Molecular Biology
- Albert J. Kooistra
- Gáspár Pándy-Szekeres
- David E. Gloriam
- Alibek Mamyrbekov
- György M. Keserü
- Christian Munk
- Stefan Mordalski
- Mauricio Esguerra
Citations in the corpus
- GPCRdb in 2021: integrating GPCR sequence, structure and function (2020, background): “References used to cite different GPCRdb resources Scope Title Authors Year Journal Ref Main reference (combine with reference for the below) GPCRdb in 2021: Integrating GPCR sequence, structure and function Kooistra et al. 2021 Nucleic Acids Research (36) Drugs, drug targets and indications Trends ”
- G protein-coupled receptors: structure- and function-based drug discovery (2021, background): “Class B This class of GPCRs is divided into two subfamilies: secretin (B1) and adhesion (B2), containing 15 and 33 members, respectively.(4,21) Secretin subfamily members are characteristic of large extracellular domains (ECDs) and bind to vasoactive intestinal peptide (VIP), pituitary adenylate cyc”