Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury.

By J. Bouchard, Sharon B. Soroko, Glenn M. Chertow, Jonathan Himmelfarb, T. Ikizler, E. Paganini, R. Mehta. Kidney International, 2009

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Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality* (2011, background): “Furthermore, they found that independent of the severity of renal failure, volume overload decreases the likelihood of subsequent renal recovery (21), implying causation with respect to worsening renal failure.”
Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1) (2013, background): “While fl uid resuscitation is widely believed to be protective, large multicenter studies have also shown that a positive fl uid balance is associated with increased 60-day mortality [22-24].”
Acute kidney injury in sepsis (2017, background): “Fluid accumulation was associated with adverse outcomes and increased mortality from the Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock [57] and in the Fluids and Catheters Treatment [58] trials, and in the Program to Improve Care in Acute Renal Disease group [59], with per”