Large-Scale Brain Systems in ADHD: Beyond the Prefrontal-Striatal Model
By F. X. Castellanos, Erika Proal. Trends in Cognitive Sciences, 2011
747 citations recorded by the source corpus.
Attention-deficit/hyperactivity disorder (ADHD) has long been thought to reflect dysfunction of prefrontal-striatal circuitry, with involvement of other circuits largely ignored. Recent advances in systems neuroscience-based approaches to brain dysfunction enable the development of models of ADHD pathophysiology that encompass a number of different large-scale “resting state” networks. Here we review progress in delineating large-scale neural systems and illustrate their relevance to ADHD. We relate frontoparietal, dorsal attentional, motor, visual, and default networks to the ADHD functional and structural literature. Insights emerging from mapping intrinsic brain connectivity networks provide a potentially mechanistic framework for understanding aspects of ADHD, such as neuropsychological and behavioral inconsistency, and the possible role of primary visual cortex in attentional dysfunction in the disorder.
Subfields: Cognitive Neuroscience, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/4b344d2067cfe616c74e9d27ba030fae8548825a
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cognitive Neuroscience
- Robert Leech
- David J. Sharp
- Antoine Lutz
- Richard J. Davidson
- Joel T. Nigg
- Cortland J. Dahl
- Ellen Leibenluft
- B. Headey
In Psychiatry and Mental health
- Richard J. Davidson
- Antoine Lutz
- Robert Leech
- Joel T. Nigg
- David J. Sharp
- Naomi P. Friedman
- A. Diamond
- D. Follmer
Citations in the corpus
- Emotion Dysregulation in Attention Deficit Hyperactivity Disorder. (2016, background): “in common with the concept of multiple but overlapping pathways to ADHD (103, 110).”
- The social brain in psychiatric and neurological disorders (2012, neutral): “Network perspectives are now being widely applied to the study of neurological and psychiatric patients [111,112], representing a shift in emphasis from specific brain regions to specific brain networks.”
- The role of the posterior cingulate cortex in cognition and disease. (2014, background): “These metabolic changes might reflect damage in remote but connected regions (Johnson et al., 1998).”
- Clinical applications of the functional connectome (2013, neutral): “Beyond implicating DN dysregulation in these disorders, current imaging methods and diagnostic category-based frameworks are unable to provide an understanding of the underlyingmechanisms at the systems level and their behavioral associations (Castellanos and Proal, 2012).”
- Reconstructing and deconstructing the self: cognitive mechanisms in meditation practice. (2015, background): “The inability to regulate attentional processes has been linked to ADHD [30], addiction [31], and other forms of psychopathology [32,33], as well as to abnormalities in brain structure and function [34].”