HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

By T. Roberts, A. Idris, Jasmyn A. Dunn, G. Kelly, Carol M Burnton, Samantha S Hodgson, Lani L Hardy, Valérie Garceau, M. Sweet, I. Ross and 2 more. Science, 2009

881 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4b2c057e67046d236173c336d7ae4c7fd465eee5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. T. Kanneganti
2. Kate Schroder
3. Yaqiu Wang
4. S. Man
5. J. Tschopp
6. Antero Salminen
7. K. Kaarniranta
8. Shizuo Akira

In Molecular Biology

1. T. Kanneganti
2. Kate Schroder
3. S. Man
4. Yaqiu Wang
5. D. Sharma
6. J. Tschopp
7. G. Núñez
8. M. Lamkanfi

Citations in the corpus

• The inflammasomes. (2010, positive): “The AIM2 Inflammasome The recent identification of the HIN-200 family member, AIM2, as a cytosolic double-stranded DNA (dsDNA) sensor that induces caspase-1-dependent IL-1b maturation is an important advance in the inflammasome field (Bürckstümmer et al., 2009; Fernandes-Alnemri et al., 2009; Hornun”
• Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? (2015, neutral): “AIM2 inflammasomes contain a HIN200 domain, which preferentially binds to cytosolic double-stranded DNA, and a pyrin domain for ASC recruitment, leading to the proteolytic cleavage of caspase-1 through CARD-CARD interactions (111).”
• From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways (2021, background): “Later reports found apoptotic caspase activity in wild type cells in response to various pyroptotic stimuli [93,95], arguing that the previously observed switch between pyroptosis and apoptosis is actually the result of the phenotypic characteristics of apoptosis being masked by the more rapid…”