Recent Progress in Ferroptosis Inducers for Cancer Therapy
By Chen Liang, Xinglin Zhang, Mengsu Yang, Xiaochen Dong. Advances in Materials, 2019
1,308 citations recorded by the source corpus.
Ferroptosis is a newly discovered form of regulated cell death that is the nexus between metabolism, redox biology, and human health. Emerging evidence shows the potential of triggering ferroptosis for cancer therapy, particularly for eradicating aggressive malignancies that are resistant to traditional therapies. Recently, there has been a great deal of effort to design and develop anticancer drugs based on ferroptosis induction. Recent advances of ferroptosis‐inducing agents at the intersection of chemistry, materials science, and cancer biology are presented. The basis of ferroptosis is summarized first to highlight the feasibility and characteristics of triggering ferroptosis for cancer therapy. A literature review of ferroptosis inducers (including small molecules and nanomaterials) is then presented to delineate their design, action mechanisms, and anticancer applications. Finally, some considerations for research on ferroptosis inducers are spotlighted, followed by a discussion on the challenges and future development directions of this burgeoning field.
Subfields: Molecular Biology, Oncology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/4a9aacda1c935429bf89f2df7f4b7fcf36068244
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Citations in the corpus
- Ferroptosis in cancer therapy: a novel approach to reversing drug resistance (2022, background): “In this respect, nanoparticle ferroptosis inducers provide unique advantages [66].”
- Ferroptosis: mechanisms and links with diseases (2021, methodology): “Also, iron concentration can be measured with inductively coupled plasmaMS (ICP-MS) or Perls’ Prussian Blue staining.(5) Lipid peroxidation level is also one of the most critical indicators of ferroptosis.”