Reparative inflammation takes charge of tissue regeneration
By M. Karin, Hans Clevers. Nature, 2016
687 citations recorded by the source corpus.
Inflammation underlies many chronic and degenerative diseases, but it also mitigates infections, clears damaged cells and initiates tissue repair. Many of the mechanisms that link inflammation to damage repair and regeneration in mammals are conserved in lower organisms, indicating that it is an evolutionarily important process. Recent insights have shed light on the cellular and molecular processes through which conventional inflammatory cytokines and Wnt factors control mammalian tissue repair and regeneration. This is particularly important for regeneration in the gastrointestinal system, especially for intestine and liver tissues in which aberrant and deregulated repair results in severe pathologies.
Subfields: Genetics, Hepatology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4a39734959b29f5c50aeacedcb63e0b164451810
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Citations in the corpus
- Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease. (2019, background): “Failure to resolve inflammation, however, results in chronic inflammation and uncontrolled tissue remodelling, such as fibrosis (Karin and Clevers, 2016).”