Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

By R. Barrès, M. Osler, Jie Yan, A. Rune, T. Fritz, K. Caidahl, A. Krook, J. Zierath. Cell Metabolism, 2009

632 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4a04e95dbe0297f0a51059b2ab7890362fad1e57

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Zierath
2. B. Egan
3. C. Ling
4. Steven R Smith

In Physiology

1. J. Zierath
2. B. Egan
3. S. Fried

Citations in the corpus

• Acute exercise remodels promoter methylation in human skeletal muscle. (2012, background): “Evidence is emerging that epigenetic modifications through DNA methylation contribute to the increased risk and development of metabolic disease by modifying the expression of genes controlling whole body energy and glucose homeostasis (Barrès et al., 2009; Klose and Bird, 2006).”
• A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue (2013, neutral): “Recent studies in human skeletal muscle and pancreatic islets point towards the involvement of epigenetic modifications in the regulation of genes important for glucose metabolism and the pathogenesis of T2D [11,12,16–21].”
• PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “In muscle cells, PGC-1α promoter methylation by DNA methyltransferase 3B (DNMT3B) represses PGC-1α expression in response to high levels of fatty acids [25].”
• Epigenetics in Human Obesity and Type 2 Diabetes (2019, background): “Only a decade ago, the first epigenetics studies were performed in pancreatic islets and skeletal muscle from patients with T2D (Barrès et al., 2009; Ling et al., 2008).”
• Sex differences in human adipose tissues – the biology of pear shape (2012, background): “Recent studies showing that acute exercise, overfeeding, and type 2 diabetes can modulate gene expression in skeletal muscle through epigenetic mechanisms [71-73] open the exciting scenario that lifestyle factors can interact with developmental programming to regulate adipose tissue mass and distrib”