Chromatin fibers are formed by heterogeneous groups of nucleosomes in vivo.

By M. A. Ricci, Carlo Manzo, M. Garcia-Parajo, M. Lakadamyali, M. Cosma. 2015

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In Molecular Biology

Citations in the corpus

Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes (2015, background): “This fiber is widely believed to coil into the larger, stiffer, 30-nm fiber, although recent studies using microscopy, electron spectroscopy, and X-ray scattering have failed to find evidence for 30-nm fibers in vivo (29, 30).”
Structural Mechanisms of Nucleosome Recognition by Linker Histones (2015, background): “, 2014) or heterogeneous groups of nucleosomes that are associated with linker histones (Ricci et al., 2015).”
Topological polymorphism of nucleosome fibers and folding of chromatin (2021, background): “By contrast, the mesoscale modeling of chromatin (24,29) showed that the intrafiber NRL variations have a profound impact on chromatin structure, with a wide range of different architectures emerging, in agreement with high-resolution imaging data (9,13).”
ChromEMT: Visualizing 3D chromatin structure and compaction n interphase and mitotic cells (2017, background): “Cryo-EM (19, 20), x-ray scattering (21), ESI (22, 23), and superresolution studies (30) also failed to detect higher-order fibers with a 30-nm periodicity, suggesting that chromatin may have an 11-nm spacing.”
Revisit of reconstituted 30-nm nucleosome arrays reveals an ensemble of dynamic structures (2018, methodology): “[46], electron microscopy-assisted nucleosome interaction capture cross-linking [47], in situ spatially correlated DNA cleavage mapping [20] and ChromEMT [48].”