Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion.

By B. Keselowsky, D. Collard, Andrés J. García. Journal of Biomedical Materials Research. Part A, 2003

924 citations recorded by the source corpus.

Subfields: Electrical and Electronic Engineering, Immunology and Allergy, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/49cc3924ee203765b56b9c1153594a3d917379f8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Electrical and Electronic Engineering

1. Rachit Agarwal
2. Andrés J. García

In Immunology and Allergy

1. Rachit Agarwal
2. David T. Chang
3. James M. Anderson
4. Analiz Rodriguez
5. Andrés J. García

In Surfaces, Coatings and Films

1. Rachit Agarwal
2. Andrés J. García

Citations in the corpus

• Mammalian Cell Behavior on Hydrophobic Substrates: Influence of Surface Properties (2019, result): “surfaces with amine and hydroxyl groups confirmed alkaline phosphatase enzymatic activity and matrix mineralization, and up-regulated osteoblast-specific gene expression in comparison with that observed with surfaces functionalized with alkyl and carboxyl groups [56].”
• Foreign body reaction to biomaterials. (2008, background): “Surfaces with varying properties promote differential cellular integrin binding to the absorbed protein layer[43–46] Subsequent material dependent differences in cell adhesion and cytoskeletal rearrangement correlate to differences in phosphorylation of FAK and ERK[47, 48] and differences in recruit”
• Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair (2015, methodology): “t1:4 Titanium t1:5 (Ti–6Al–4V) t1:6 Stainless steel t1:7 (316 grade) Increasing surface roughness [41–48] 8 NH2 and OH functional groups on the surface [51,52] 9 Making surface hydrophilic and increasing its wettability [49,50]”
• Surface engineering approaches to micropattern surfaces for cell-based assays. (2006, background): “), their surface density [2–4] and spatial distribution [1,5,6] as well as their conformation [7], have been demonstrated to be important surface cues.”
• Cell Responses to Surface and Architecture of Tissue Engineering Scaffolds (2011, background): “OH, -COOH, and -NH 2 groups) modulated Fn adsorption and direct integrin binding and specificity to control cell adhesion of MC3T3 osteoblasts to Fn-coated surfaces followed the trend: OH >COOH =NH 2 > CH3 (Keselowsky et al., 2003).”