The mystery of membrane organization: composition, regulation and physiological relevance of lipid rafts
By E. Sezgin, Ilya Levental, S. Mayor, Christian Eggeling. Nature reviews. Molecular cell biology, 2017
1,817 citations recorded by the source corpus.
Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large number of studies have focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical principle for a subtype of such lateral membrane heterogeneity, in which the preferential associations between cholesterol and saturated lipids drive the formation of relatively packed (or ordered) membrane domains that selectively recruit certain lipids and proteins. Recent studies have yielded new insights into this mechanism and its relevance in vivo, owing primarily to the development of improved biochemical and biophysical technologies.
Subfields: Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/49b2356120411dd5945da922789a216b31dcd2a7
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Citations in the corpus
- CHARMM-GUI Membrane Builder for Complex Biological Membrane Simulations with Glycolipids and Lipoglycans. (2018, background): “Cell membranes have a wide variety of lipids that provide a matrix to host integral membrane proteins and recruit peripheral membrane proteins, thus actively participating in cellular membrane functions together with these proteins 1,2 .”
- Computational Modeling of Realistic Cell Membranes (2019, background): “303,304 The propensity to form distinct phases is already found in model membranes composed of ternary mixtures of saturated lipids, unsaturated lipids, and cholesterol, capable of forming coexisting liquid-ordered (Lo) and liquid-disordered (Ld) domains.”