Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics
By Sung Il Park, D. Brenner, G. Shin, Clinton D Morgan, B. Copits, Ha Uk Chung, M. Pullen, K. N. Noh, S. Davidson, S. Oh and 18 more. Nature Biotechnology, 2015
726 citations recorded by the source corpus.
Optogenetics allows rapid, temporally specific control of neuronal activity by targeted expression and activation of light-sensitive proteins. Implementation typically requires remote light sources and fiber-optic delivery schemes that impose considerable physical constraints on natural behaviors. In this report we bypass these limitations using technologies that combine thin, mechanically soft neural interfaces with fully implantable, stretchable wireless radio power and control systems. The resulting devices achieve optogenetic modulation of the spinal cord and peripheral nervous system. This is demonstrated with two form factors; stretchable film appliqués that interface directly with peripheral nerves, and flexible filaments that insert into the narrow confines of the spinal epidural space. These soft, thin devices are minimally invasive, and histological tests suggest they can be used in chronic studies. We demonstrate the power of this technology by modulating peripheral and spinal pain circuitry, providing evidence for the potential widespread use of these devices in research and future clinical applications of optogenetics outside the brain.
Subfields: Cellular and Molecular Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/49b0919abf8c4de72cc56bea1eddfeb1ae490e9b
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In Cellular and Molecular Neuroscience
Citations in the corpus
- Flexible near field wireless optoelectronics as subdermal implants for broad applications in optogenetics (2017, positive): “Other alterations will allow application to alternative optogenetic targets, including the spinal cord and sciatic nerve (Montgomery et al., 2015; Park et al., 2015a).”
- Inorganic semiconducting materials for flexible and stretchable electronics (2017, methodology): “Reprinted with permission from Park et al.89 Copyright 2015 Nature Publishing Group npj Flexible Electronics (2017) 4 Published in partnership with Nanjing Tech University actively multiplexed sensor arrays in thin flexible formats allow mapping of electrical activity on the surface of the brain wit”