μ-Opioid Receptor Knockout Mice Do Not Self-Administer Alcohol
By A. Roberts, J. McDonald, C. Heyser, Brigitte L. Kieffer, H. Matthes, G. Koob, L. Gold. Journal of Pharmacology and Experimental Therapeutics, 2000
334 citations recorded by the source corpus.
Opioid peptides long have been hypothesized to play a role in ethanol reinforcement. Neuropharmacological studies have shown that opioid receptor antagonists decrease ethanol self-administration in rodents and prevent relapse in humans. However, the exact mechanism for such powerful effects has remained elusive. The availability of μ-opioid receptor knockout mice has made possible the direct examination of the role of the μ-opioid receptor in mediating ethanol self-administration. In the present experiments, both nosepoke and lever operant ethanol self-administration and several tests of two bottle-choice ethanol drinking were studied in these genetically engineered mice. In no case did knockout mice show evidence of ethanol self-administration, and, in fact, these mice showed evidence of an aversion to ethanol under several experimental conditions. These data provide new evidence for a critical role for μ-opioid receptors in ethanol self-administration assessed with a variety of behavioral paradigms and new insights into the neuropharmacological basis for ethanol reinforcement.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/498e34579dc5cf1285ca2742386b54b86d49f36e
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Citations in the corpus
- Alcoholism: a systems approach from molecular physiology to addictive behavior. (2009, background): “In addition, -opioid receptor knockout mice do not self-administer alcohol under several different test conditions (399) and, in accordance, selective antagonists acting at -opioid receptors are able to reduce alcohol consumption (211).”
- Drug Addiction, Dysregulation of Reward, and Allostasis (2001, background): “Mice bearing knockout of the mu opioid receptor do not drink alcohol (Roberts et al. 2000b).”
- Reward Processing by the Opioid System in the Brain (2009, positive): “133) induced CPP were undetectable, alcohol self-administration was abolished (31, 317), and ethanol consumption was decreased (31, 317).”