The insulin-like growth factor system and cancer.

By D. Leroith, C. Roberts. Cancer Letters, 2003

931 citations recorded by the source corpus.

The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an important growth factor system involved in both the development of the organism and the maintenance of normal function of many cells of the body. The system also has powerful anti-apoptotic effects. More recently, evidence has accrued to demonstrate that the IGFs play an important role in cancer. Individuals with serum IGF-II levels in the upper quartile of the normal range (and IGF binding protein-3 levels in the lower quartiles) have a relative risk for developing breast, prostate, colon and lung cancer. IGF-II is commonly expressed by tumor cells and may act as an autocrine growth factor; occasionally even reaching target tissues and causing tumor-induced hypoglycemia. The IGF-I receptor is commonly (though not always) overexpressed in many cancers, and many recent studies have identified new signaling pathways emanating from the IGF-I receptor that affect cancer cell proliferation, adhesion, migration and cell death; functions that are critical for cancer cell survival and metastases. In this review, many aspects of the IGF system and its relationship to cancer will be discussed.

Subfields: Cancer Research, Endocrinology, Diabetes and Metabolism, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/498302ee0aff783091f58fab112d2e3c1380f739

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In Endocrinology, Diabetes and Metabolism

In Molecular Biology

V. Lee

Citations in the corpus

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. (2004, neutral): “in (LeRoith and Roberts, 2003).”
Effects of exercise and diet on chronic disease. (2005, background): “IGF is a potent mitogenic factor in tissues including prostate (221, 418).”
Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size (2005, background): “IGF1 acts through the type 1 IGF receptor to modulate an evolutionarily conserved pathway of molecules involved in the regulation of growth and metabolism (38, 53).”