Activation and regulation of the inflammasomes

By E. Latz, S. Xiao, A. Stutz. Nature reviews. Immunology, 2013

2,773 citations recorded by the source corpus.

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform — the apoptosome — that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/495c25cdb86fc1a29e8e3da4a1fb87f957c43044

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Zou
2. Jacques Banchereau
3. A. Grebe
4. C. Secombes
5. E. Latz
6. K. Palucka
7. Florian Hoss

In Physiology

1. Dan Xiao
2. Weifeng Zhang
3. Haibin Xia
4. Q. Mao
5. E. Latz

Citations in the corpus

• Human Monocytes Engage an Alternative Inflammasome Pathway. (2016, neutral): “, via Toll-like receptor (TLR) signaling, whereas a second signal (signal 2) is recognized in order to activate the inflammasome (Guo et al., 2015; Lamkanfi and Dixit, 2014; Latz et al., 2013; Wen et al., 2013).”
• Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “As expected, INT-777, a semi-synthetic TGR5 agonist (Pellicciari et al., 2009), markedly repressed caspase-1 maturation and IL1b or IL-18 but not the TNF-a secretion induced by nigericin, similar to LCA (Figures 2A–2C and S2A).”
• The pore forming protein gasdermin D regulates interleukin-1 secretion from living macrophages (2017, neutral): “Glycine was used to prevent membrane rupture downstream of the normally pyroptotic NLRP3 inflammasome activator nigericin after LPS priming (Latz et al., 2013).”
• Role of neuroinflammation in neurodegeneration development (2023, background): “, ATP, uric acid, and aggregates).(348,349) Activating NLRP3 is a very complex process, which makes it unique among the inflammasomes.”