T-cell function and migration. Two sides of the same coin.

By Ulrich H. von Andrian, C. Mackay. New England Journal of Medicine, 2000

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Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. (2007, background): “Naive T and B lymphocytes, another population of recirculating cells, gain access to the lymphatic vasculature after homing to SLOs, which they reach through specialized postcapillary venules, the high endothelial venule (HEV) (von Andrian and Mackay, 2000).”
Chemokines and chemokine receptors in leukocyte trafficking. (2002, background): “Entry of naive lymphocytes into lymph nodes occurs via transmigration across high endothelial venules beginning with a three-step sequential process involving L-selectin-mediated rolling, a chemokine-induced signaling event, and integrin-mediated firm adhesion to the endothelium (27, 184).”