External validity of randomised controlled trials: "to whom do the results of this trial apply?".

By Peter M. Rothwell. 2005

2,539 citations recorded by the source corpus.

Subfields: Economics and Econometrics, General Health Professions, Statistics and Probability

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Citations in the corpus

Variable generalization performance of a deep learning model to detect pneumonia in chest radiographs: A cross-sectional study (2018, methodology): “In the biomedical imaging context, we can contrast ‘internal’ model performance on new, previously unseen data gathered from the same hospital system(s) used for model training with ‘external’ model performance on new, previously unseen data from different hospital systems [9, 10].”
Analysis of randomized comparative clinical trial data for personalized treatment selections. (2011, result): “However, there are numerous examples that the results from the so-called subgroup analyses, which were not properly planned or executed subgroup analyses, could not be validated (Rothwell, 2005; Pfeffer and Jarcho, 2006; Wang and others, 2007).”
Effectiveness of long-term psychodynamic psychotherapy: a meta-analysis. (2008, background): “However, their clinical representativeness (external validity) can be limited by strict experimental control.(26) In contrast, effectiveness studies are carried out under the conditions of clinical practice.”
Understanding and misunderstanding randomized controlled trials (2016, neutral): “More generally, Horton (2000) gives a strong dissent and Rothwell (2005) provides arguments on both sides of the question.”
Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration. (2008, background): “These differences were not mentioned in any of the publications for the European Carotid Surgery Trial, yet they probably had an important impact on the outcomes (111).”
GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. (2013, background): “For instance, a recommendation regarding carotid endarterectomy might vary depending on the extent of delay between a patient’s presentation with symptoms suggesting carotid stenosis and the performance of surgery [17].”