Interactions between the microbiota, immune and nervous systems in health and disease

By Thomas C. Fung, C. A. Olson, E. Hsiao. Nature Neuroscience, 2017

1,652 citations recorded by the source corpus.

The diverse collection of microorganisms that inhabit the gastrointestinal tract, collectively called the gut microbiota, profoundly influences many aspects of host physiology, including nutrient metabolism, resistance to infection and immune system development. Studies investigating the gut–brain axis demonstrate a critical role for the gut microbiota in orchestrating brain development and behavior, and the immune system is emerging as an important regulator of these interactions. Intestinal microbes modulate the maturation and function of tissue-resident immune cells in the CNS. Microbes also influence the activation of peripheral immune cells, which regulate responses to neuroinflammation, brain injury, autoimmunity and neurogenesis. Accordingly, both the gut microbiota and immune system are implicated in the etiopathogenesis or manifestation of neurodevelopmental, psychiatric and neurodegenerative diseases, such as autism spectrum disorder, depression and Alzheimer's disease. In this review, we discuss the role of CNS-resident and peripheral immune pathways in microbiota–gut–brain communication during health and neurological disease.

Subfields: Biological Psychiatry, Gastroenterology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/48f698ab29a167efa4c1bbd22c3c7c185b485eb0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. Ygor P. Silva
2. A. Bernardi
3. R. Frozza
4. Philip Strandwitz

In Gastroenterology

1. Philip Strandwitz
2. Ygor P. Silva
3. A. Bernardi
4. R. Frozza

In Molecular Biology

1. Philip Strandwitz
2. M. De Angelis
3. Ygor P. Silva
4. J. Durack
5. S. Lynch
6. M. Vacca
7. A. Bernardi
8. P. Portincasa

Citations in the corpus

• The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Behavioral disorders The gut microbiota has recently emerged as an important mediator of biochemical signaling between the GI tract and the central nervous system, more commonly referred to as the gut– brain axis (Fung et al., 2017).”
• Neurotransmitter modulation by the gut microbiota (2018, background): “, 2015), and interacts with the enteric and central nervous systems (ENS and CNS, respectively) via communication along the ‘‘gut-brain-axis” (Fung et al., 2017).”
• Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis (2019, background): “In humans, evidence for interplay between gastrointestinal pathology and neuropsychiatric conditions has been reported in conditions such as anxiety, depression, and autism [12, 16].”
• Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis (2022, background): “Butyrate induces Treg differentiation and plays a role in the control of inflammation [54].”
• The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020, background): “One of the best-documented effects of SCFAs is on the immune system since butyrate is capable of inducing Treg differentiation and controlling inflammation (17, 23, 24, 87).”
• Gut Microbiota is Altered in Patients with Alzheimer’s Disease (2018, positive): “Thegut microbiotamaycommunicatewithbrainthrough neural,endocrineandimmunepathways[17,18].”