A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling

By C. Revankar, D. Cimino, L. Sklar, J. B. Arterburn, E. Prossnitz. Science, 2005

2,346 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/48c867c42199df185288feef056d1d5b93864da2

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In Endocrinology, Diabetes and Metabolism

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Citations in the corpus

The complete nuclear estrogen receptor family in the rainbow trout: Discovery of the novel ERα2 and both ERβ isoforms (2007, background): “Recent evidence demonstrates that the ERs involved in the nongenomic pathway belong to the G protein-coupled receptor family, which is distinct and different from nuclear ERs (Revankar et al., 2005; Thomas et al., 2005).”
Mechanistic Pathways of Sex Differences in Cardiovascular Disease. (2017, background): “A third receptor, the G protein-coupled receptor (GPR30), has been proposed to be an ER mediating nongenomic effects of E2 (117, 118, 335), whose role, though, as an actual ER binding E2 in a direct manner or an interacting partner of the classical ER has been debated (221, 297).”
Computational Methods in Drug Discovery (2014, background): “The GPCR GPR30 has recently been shown to bind estrogen with high affinity and its specific role in estrogen-regulated signaling is being studied (Revankar et al., 2005).”
Possible roles of sex steroids in the control of reproduction in bivalve molluscs (2007, background): “Finally, a novel family of G-protein receptors which bind to sex steroids has recently been discovered in vertebrates ( Revankar et al., 2005; Thomas et al., 2006, 2005) and orthologues in the invertebrates might explain many of the effects of steroids in these animals.”
G-protein-coupled receptors and cancer (2007, background): “The activation of GPR30 stimulates cyclic AMP (cAMP) and phosphatidylinositol trisphosphate (PIP 3 ) accumulation concomitant with increased phosphatidylinositol bisphosphate (PIP 2 ) hydrolysis, increases intracellular calcium levels by stimulating Gα s , Gα i and Gα q”
Virtual and biomolecular screening converge on a selective agonist for GPR30 (2006, background): “As GPR30 is known to bind many of the same ligands as classical estrogen receptors (for example, 17b-estradiol (2), 4-hydroxytamoxifen (3), ICI182,780 (4))4–6, though with differing cellular effects (for example, ICI182,780 is an ER antagonist but a GPR30 agonist), we screened a library of diverse c”
Estrogen synthesis and signaling pathways during ageing: from periphery to brain (2013, background): “GPR30 is classified as a membraneassociated ER as it mediates estrogen-induced G-protein activation [58].”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “] Similarly acting nongenomic pathways, potentially involving newly discovered membrane-associated estrogen receptors, appear to regulate extranuclear estrogen signalling pathways that can affect cell proliferation (Björnström & Sjöberg, 2005; Revankar et al., 2005; Song et al., 2006; Yager & Davids”
The G protein-coupled estrogen receptor GPER in health and disease (2011, background): “Two studies published in 2005 described binding of 17β-estradiol to GPR30 in GPR30-transfected COS7 and HEK293 cells, as well as various breast cancer cell lines”
Estrogen Rapidly Enhances Incisional Pain of Ovariectomized Rats Primarily through the G Protein-Coupled Estrogen Receptor (2014, background): “Several studies have shown that E2 can induce a rapid increase (within minutes and even seconds) of intracellular cAMP and Ca concentration through GPER [1,15–17].”