Glioblastoma stem-like cells give rise to tumour endothelium

By Rong Wang, Kalyani Chadalavada, J. Wilshire, Urszula Kowalik, K. Hovinga, Adam Geber, B. Fligelman, M. Leversha, C. Brennan, V. Tabar. Nature, 2010

1,252 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/48af573b9892a25e08b5936cdc0c886d8bfc7eac

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Citations in the corpus

Targeting cancer stem cell pathways for cancer therapy (2020, background): “CSCs are also found near ECs in other cancers, such as papilloma and colorectal cancer.418,419 A study also showed that CD133+/CD144− glioma stem cell-like cells differentiate into cancer cells and endothelial progenitor cells and finally into mature ECs.420 CSCs differentiate into cancer vascular s”
Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma (2011, background): “In view of recent findings indicating that GBMs can contribute to their own vascular supply (26, 27), it will be of interest to determine the VEGF dependency of these tumor-derived endothelial cells and their response to anti-angiogenic treatment.”
Tumor Metastasis: Molecular Insights and Evolving Paradigms (2011, neutral): “…into bona fide endothelial cells that are competent to contribute to the tumor neovasculature suggests a previously unexpected level of plasticity and functional heterogeneity within tumor cell populations and their associated stromal compartments (Ricci-Vitiani et al., 2010; Wang et al., 2010).”
Cancer stem cells: current status and evolving complexities. (2012, background): “There has been considerable interest in the development of monoclonal antibodies to target CSCs. Markers differentially expressed between normal stem cells and LSCs have been utilized to specifically target LSCs in human AML, including CD44 (Jin et al., 2006), IL3R (Jin et al., 2009), and the immuno”
Molecular mechanisms and clinical applications of angiogenesis (2011, background): “Putative cancer stem-like cells can even generate tumour endotheliu”
Hallmarks of cancer: the next generation. (2011, neutral): “…possibly their associated CSC subpopulations) to transdifferentiate into endo-thelial-like cells that can substitute for bona ﬁde host-derived endothelial cells in forming a tumor-associated neovasculature (Soda et al., 2011; El Hallani et al., 2010; Ricci-Vitiani et al., 2010; Wang et al., 2010).”
Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth (2013, neutral): “Within this context, there was an excitement generated by reports suggesting that GSCs may transdifferentiate into ECs (Ricci-Vitiani et al., 2010; Soda et al., 2011; Wang et al., 2010).”
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells (2011, result): “None of the alterations have any direct impact on the validity of our conclusions, which were also substantially confirmed in papers published by other independent group”
Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions (2014, background): “pericytes, which may be a mechanism for vasculogenic mimicry [178–180].”
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma (2014, background): “Glioblastoma is also postulated to contain more differentiated cells (DGCs) that can be expanded as adherent monolayers in serum (27, 40).”