Superoxide is the major reactive oxygen species regulating autophagy
By Yongqiang Chen, M. Azad, S. Gibson. Cell Death and Differentiation, 2009
785 citations recorded by the source corpus.
Subfields: Epidemiology
View Paper: https://www.semanticscholar.org/paper/489050d650362888a193b765e44f2e9fd7d16309
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
- Yongqiang Chen
- D. Klionsky
- F. Cecconi
- Navdeep S. Chandel
- J. Tschopp
- A. Gorman
- Simone Fulda
- Afshin Samali
Citations in the corpus
- The inflammasomes. (2010, background): “Interestingly, ROS derived from either the mitochondrial electron transport chain or NAPDH oxidases upregulates autophagy (Chen et al., 2009; Huang et al., 2009).”
- Reactive oxygen species and mitochondria: A nexus of cellular homeostasis (2015, background): “Catalase, which decreases both superoxide and hydrogen peroxide levels, also suppresses starvation-induced autophagy [10].”
- Broad targeting of resistance to apoptosis in cancer (2015, background): “OS, especially mitochondrial ROS, serve as signaling molecules in nducing autophagy [69].”
- ROS Function in Redox Signaling and Oxidative Stress (2014, background): “However, it is important to note that superoxide does not indiscriminately damage proteins: a specific set of proteins that are sensitive to inactivation by superoxide activate signaling pathways that either promote adaptation to elevated superoxide or initiate cell death [11].”
- Oxidative stress and autophagy: the clash between damage and metabolic needs (2014, background): “A detailed work from Chen et al.51 proposes that O2 .”
- Cellular Stress Responses: Cell Survival and Cell Death (2010, background): “Similarly, accumulating evidence suggests a role for O2 •− in the activation of autophagy [200].”
- Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling (2018, neutral): “O2 has also been shown to regulate autophagy (Chen et al., 2009).”
- The regulation of autophagy – unanswered questions (2011, background): “In recent years, studies have demonstrated that ROS can also regulate autophagy (Chen et al., 2009; Huang et al., 2009; ScherzShouval et al., 2007).”