IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data

By J. Sharman, C. Mpamhanga, M. Spedding, P. Germain, Bart Staels, C. Dacquet, V. Laudet, A. Harmar. 2010

112 citations recorded by the source corpus.

The IUPHAR database is an established online reference resource for several important classes of human drug targets and related proteins. As well as providing recommended nomenclature, the database integrates information on the chemical, genetic, functional and pathophysiological properties of receptors and ion channels, curated and peer-reviewed from the biomedical literature by a network of experts. The database now includes information on 616 gene products from four superfamilies in human and rodent model organisms: G protein-coupled receptors, voltage- and ligand-gated ion channels and, in a recent update, 49 nuclear hormone receptors (NHRs). New data types for NHRs include details on co-regulators, DNA binding motifs, target genes and 3D structures. Other recent developments include curation of the chemical structures of approximately 2000 ligand molecules, providing electronic descriptors, identifiers, link-outs and calculated molecular properties, all available via enhanced ligand pages. The interface now provides intelligent tools for the visualization and exploration of ligand structure-activity relationships and the structural diversity of compounds active at each target. The database is freely available at http://www.iuphar-db.org.

Subfields: Computational Theory and Mathematics, Molecular Biology, Pharmacology

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In Computational Theory and Mathematics

1. Anna Gaulton
2. Anne Hersey
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In Molecular Biology

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Citations in the corpus

• ChEMBL: a large-scale bioactivity database for drug discovery (2011, background): “BRENDA provides binding constants for enzymes (14), IUPHAR contains ligand information for receptors and ion channels (15), while GLIDA (16) and GPCRDB (17) provide information specifically for G-protein-coupled receptors.”
• The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands (2013, methodology): “For further details on the types of information that are provided in the detailed view see previous publications (3,15,29).”