The locus coeruleus and noradrenergic modulation of cognition

By Susan Sara. 2009

1,778 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Wulfram Gerstner
2. J. Urgen Schmidhuber
3. Nicolas Frémaux
4. Robert Froemke
5. Gianluca Baldassarre
6. Henry Markram
7. Marco Mirolli
8. Y. Dan

In Cognitive Neuroscience

1. Wulfram Gerstner
2. J. Urgen Schmidhuber
3. Gianluca Baldassarre
4. Marco Mirolli
5. Nicolas Frémaux
6. Robert Froemke
7. Francesco Mannella
8. Henry Markram

Citations in the corpus

• What are intrinsic motivations? A biological perspective (2011, background): “In this respect, it has been shown that LC activates in correspondence to novel stimuli and objects encountered during free exploration [42], [43], and then rapidly habituates after few experiences.”
• Intrinsically motivated action-outcome learning and goal-based action recall: a system-level bio-constrained computational model. (2013, background): “(LC) Signals violations of expectations Sara et al. (1994); Sara (2009)”
• Pupil diameter covaries with BOLD activity in human locus coeruleus (2014, background): “The locus coeruleus (LC) is a small nucleus in the dorsal pons that exerts powerful effects on neural processing via secretion of the neuromodulator noradrenaline [NA; Berridge and Waterhouse, 2003; Sara, 2009].”
• Awake reactivation of emotional memory traces through hippocampal-neocortical interactions (2016, positive): “Emotional arousal was indicated by an increased pupil dilation, an indirect index of norepinephrine release (Sara, 2009), during fear learning in response to exemplars of the category linked to a shock.”
• Plasticity of Cortical Excitatory-Inhibitory Balance (2015, background): “Noradrenalin is a catecholamine neuromodulator also involved in attention and arousal (AstonJones & Cohen 2005, Eldar et al. 2013, Sara 2009), but the cholinergic and noradrenergic systems www.annualreviews.org • Cortical Synaptic Plasticity 207 A nn u.”
• The Dynamics of Functional Brain Networks: Integrated Network States during Cognitive Task Performance (2015, positive): “There is a wealth of evidence to suggest that neuromodulatory inputs can have complex, non-linear effects on network organization and behavior (Bargmann and Marder, 2013), perhaps as a result of the balance between the ‘‘top-down’’ attentional modulation of network architecture (Sara, 2009) and ‘‘bo”
• The neuro-scientific foundations of the exploration-exploitation dilemma (2010, background): “However, multiple recent findings suggest that this system plays a more complex and specific role in the control of behavior by contributing to the optimization of behavioral performance (Sara, 2009).”
• Beyond eye gaze: What else can eyetracking reveal about cognition and cognitive development? (2016, background): “The LC is a small ucleus in the brainstem that plays a central role in the regulation f physiological arousal (Samuels and Szabadi, 2008) and cognitive unctioning (Sara, 2009).”
• An intrinsic value system for developing multiple invariant representations with incremental slowness learning (2013, background): “The LC-NE system is more traditionally thought to affect levels of arousal, but more recently has been implicated in optimization of behavioral performance [2], [49], [66].”
• Neuromodulated Spike-Timing-Dependent Plasticity, and Theory of Three-Factor Learning Rules (2016, background): “…example, noradrenaline-emitting neurons located in locus coeruleus and projecting axons to nearly all brain areas are reciprocally connected to dopaminergic neurons located in the VTA and are therefore likely to share some, but not all signaling features of dopamine-emitting neurons (Sara, 2009).”
• Pupillometry (2012, background): “One current hypothesis is that the noradrenergic system, which originates in the LC, mediates the functional integration of the whole attentional brain system (Corbetta, Patel, & Shulman, 2008; Coull, Büchel, Friston, & Frith, 1999; Sara, 2009).”
• Frontiers in Synaptic Neuroscience Synaptic Neuroscience (positive): “…areas are targeted and influenced by not only one, but by several neuromodulators (Bear and Singer, 1986; Zhou et al., 2001; Wang et al., 2006; Sara, 2009), and accordingly, there is experimental Frontiers in Synaptic Neuroscience www.frontiersin.org October 2010 | Volume 2 | Article 146 |…”