BrdU immunohistochemistry for studying adult neurogenesis: paradigms, pitfalls, limitations, and validation.

By P. Taupin. Brain Research Reviews, 2007

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Experience dictates stem cell fate in the adult hippocampus. (2011, neutral): “While some indirect information about cumulative cell death can be achieved through BrdU survival studies, the technique provides limited information about total populations of cells (Taupin, 2007).”
Nutrient Fluxes and Ecological Functions of Coral Reef Sponges in a Changing Ocean (2017, background): “…in high doses (at least three orders of magnitude higher than applied in the cell proliferation studies described above), its toxicity has been found to be related to delayed cell division by lengthening the cell cycle and the inability of cells to divide (e.g., Taupin 2007; De Almeida et al.”
Temporal Interference Stimulation Enhances Neural Regeneration (2026, unknown): “We also injected the DNA synthesis marker bromodeoxyuridine (BrdU) [ 86 ] intraperitoneally, during the stimulation period (at D3 and D10) to examine the fate of cells that proliferated during the stimulation period (mature neural phenotype: BrdU + /NeuN + , other fate: BrdU + /NeuN-/DCX-).”