Review: Activation patterns of microglia and their identification in the human brain
By D. Boche, V. Perry, James A. R. Nicoll. Neuropathology and Applied Neurobiology, 2013
887 citations recorded by the source corpus.
Subfields: Immunology, Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/4818c276de8d7b46514d93b7c8a15558094f41ca
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Citations in the corpus
- Reactive Astrocytes: Production, Function, and Therapeutic Potential. (2017, background): “…as Tnf (Tumor Necrosis Factor), Il1b (Interleukin 1 beta), and reactive oxygen species (see Block et al., 2007) to immunosuppressive ‘‘M2-like’’ phenotypes characterized by upregulation of Chil3 (Chitinase-like 3), Fzd1 (Frizzled class receptor 1), and Arg1 (Arginase 1, see Boche et al., 2013).”
- Microglial M1/M2 polarization and metabolic states (2016, background): “In addition, within the normal CNS environment, microglia express high levels of microRNA-124, reducing expression of CD46, major histocompatibility complex-II (MHC-II) and CD11b serving to maintain the cells in a quiescent yet, surveillance state (Conrad and Dittel, 2011).”
- Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease. (2015, positive): “Microglia activated by lipopolysaccharide (LPS), IFN-γ or TNF-α is considered to be ‘‘M1’’ (‘‘classically activated’’) form of microglial (18,19).”
- Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration (2015, positive): “Similar morphological changes of glia have been reported under stress conditions (Boche et al., 2013; Pekny and Nilsson, 2005).”
- Neuroinflammation and M2 microglia: the good, the bad, and the inflamed (2014, background): “Using a full array of immune receptors, such as toll-like receptors (TLRs), nucleotidebinding oligomerization domains (NODs), NOD-like receptors, and many scavenger receptors [10,11], microglia (as well as other CNS cells, such as astrocytes) are able to recognize harmful stimuli and respond by prod”
- Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke. (2016, background): “When compared with macrophages in circulation, the typical morphology of microglia is characterized by short and fine processes, which allows them to effectively perceive and monitor even minor changes in the local brain milieu because to their large surface area that enables communication with thei”