Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis.
By Shitij Kapur, P. Seeman. American Journal of Psychiatry, 2001
1,193 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/480d00cbeb8332f4d99bb72edc7ce37da75189e7
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In Cellular and Molecular Neuroscience
In Molecular Biology
In Psychiatry and Mental health
Citations in the corpus
- A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. (2005, neutral): “Risperidone has a relatively high affinity and long dissociation latency period for D2 receptors (Kapur and Seeman, 2001; Lavalaye et al., 1999; Seeman, 2002), suggesting that patients receiving risperidone may be more likely to display adverse effects associated with DA antagonism in the striatum…”
- Ligand–receptor interaction platforms and their applications for drug discovery (2012, background): “Examining the molecular and physiochemical properties of marketed drugs has highlighted the importance of the biochemical mechanisms of action including structural, kinetic, and thermodynamic signatures of drugs for their in vivo clinical performance [18-27].”
- Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms (2019, background): “act via alternative nondopaminergic mechanisms, such as the serotonergic system, it is still the case that they all bind to dopamine receptors, and there is no clear relationship between efficacy and serotonergic effects [5].”
- Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder. (2003, neutral): “Whole body Headache 28 (27) 28 (28) 35 (35) 31 (31) Asthenia 5 (5) 8 (8) 8 (8) 6 (6) Pain 4 (4) 6 (6) 6 (6) 2 (2) Pain, extremity 6 (6) 5 (5) 6 (6) 5 (5) Infection 4 (4) 3 (3) 5 (5) 2 (2) Pain, back 7 (7) 4 (4) 1 (1) 7 (7) Accidental injury 7 (7) 5 (5) 0 0 Cardiovascular system Tachycardia 1 (1) 4 (”