Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

By L. Guelen, Ludo Pagie, É. Brasset, W. Meuleman, Marius B. Faza, W. Talhout, B. Eussen, A. Klein, L. Wessels, W. de Laat and 1 more. Nature, 2008

1,910 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/47e75641cc8c67c2006aa5e8731bf5867aa8d998

How researchers see this paper

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In Molecular Biology

1. Manel Esteller
2. W. de Laat
3. Peter A. Jones
4. S. Baylin
5. Peter W. Laird
6. E. de Wit
7. Job Dekker
8. Amos Tanay

Citations in the corpus

• Integrative annotation of chromatin elements from ENCODE data (2012, neutral): “The Quies states showed a consistent enrichment for the nuclear lamina domains mapped previously in human lung fibroblasts (32) (Supplementary Figure S21).”
• The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells. (2013, background): “This suggestion is in agreement with previous findings that LADs contain mainly transcriptionally silent genes (Guelen et al., 2008) and are mainly associated with HP1 and null domains, similarly to H1.”
• A decade of 3C technologies: insights into nuclear organization. (2012, background): “They are generally gene-poor, transcriptionally inactive, and late replicating (Guelen et al. 2008; Peric-Hupkes et al. 2010).”
• Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization (2017, neutral): “The euchromatic A- compartment contains most actively transcribed regions, while the B-compartment corresponds to megabase-sized gene-poor Lamina-Associated Domains (LADs (Guelen et al., 2008; Kind et al., 2015)) which replicate late in S-phase (Ryba et al.”
• The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes (2008, background): “Indeed, specific regions of the human genome (which are on average 500 kbp in size) bind the nuclear lamina, suggesting that lamina-binding domains serve as a structural framework to organize the genome inside the nucleus (Guelen et al., 2008).”
• Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data (2013, background): “Finally, transcriptionally inactive segments of the genome also tend to associate with each other and often can be found localized at the nuclear periphery 14 , around nucleoli 15,16 or, in Drosophila melanogaster , at subnuclear structures such as Polycomb bodies 17–19 .”
• A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “Insulator proteins such as CCCTC-binding factor (CTCF) and other”
• Distinct DNA methylomes of newborns and centenarians (2012, background): “2 × 10) occurred in lamina-associated domains of the genome (23), where cancer-type–specific DMRs have also been characterized (15, 16).”
• CTCF: Master Weaver of the Genome (2009, positive): “…range of genomic regulatory processes? van Steensel and colleagues recently identified >1300 sharply defined, large (0.1–10 Mb) genomic regions in human lung-derived fibroblasts that interact with LaminB1 and, in principle, are generally localized to the nuclear periphery (Guelen et al., 2008).”