Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects.

By Romain Daillère, Marie Vetizou, N. Waldschmitt, T. Yamazaki, C. Isnard, Vichnou Poirier-Colame, Connie P. M. Duong, C. Flament, P. Lepage, M. Roberti and 26 more. Immunity, 2016

757 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/0e7b2be9fe7bca8c6f30677b8c11957cdb9a9d7f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Rob Knight
2. Helen Y Wang
3. Changsheng Xing
4. Rong‐Fu Wang
5. L. Zitvogel
6. J. Wargo
7. Guido Kroemer
8. L. Galluzzi

In Molecular Biology

1. Rob Knight
2. Jeff Hasty
3. L. Zitvogel
4. J. Wargo
5. Noah Fierer
6. C. Lauber
7. Micah Hamady
8. Catherine A. Lozupone

In Oncology

1. L. Zitvogel
2. J. Wargo

Citations in the corpus

• Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors (2018, background): “The alteration of microbiota composition might change the tumor immune microenvironment by the homing and recirculation of lymphocytes [89, 90].”
• Homeostatic immunity and the microbiota (2017, neutral): “Cyclophosphamide (CTX), a clinically important cancer drug, also leads to intestinal damage, microbial translocation and subsequent induction of Th17, Th1 and γδT responses that, collectively, contribute to the anti-tumoral response (Daillere et al., 2016; Viaud et al., 2013).”
• Probiotic Species in the Modulation of Gut Microbiota: An Overview (2018, background): “However, alteration of the gut microbiota composition can lead to multiple diseases in humans and animals [21, 22, 28, 30].”
• Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis (2019, background): “Further studies confirm that the presence of key bacterial species, Enterococcus and Barnesiella, is both necessary and sufficient to mount effective immune responses (such as induction of memory Th1 and pathogenic Th17 responses as well as increases in tumor-specific CD4 and CD8 T cells) at tumor l”
• The microbiome and human cancer (2021, background): “Anticancer therapies have demonstrated strong links between distinct commensals and protective antitumor T cell responses: (i) Cyclophosphamide enables Enterococcus hirae to translocate and stimulate pathogenic helper T cell 17 (TH17) responses and IFN-producing CD8 T cell effectors that check tumor”