Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience.

By K. Nakazawa, L. D. Sun, M. Quirk, L. Rondi-Reig, Matthew A. Wilson, S. Tonegawa. 2003

501 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

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Citations in the corpus

The temporal paradox of Hebbian learning and homeostatic plasticity (2017, neutral): “rapidly encode new episodic information [47, 48].”
Hippocampal Plasticity across Multiple Days of Exposure to Novel Environments (2004, unknown): “Previous examinations of place cell plasticity in novel environments relied on averaging data from many neurons across wide time bins ( 3 min) (Bostock et al., 1991; Wilson and McNaughton, 1993; Nakazawa et al., 2003).”
Network dynamics underlying the formation of sparse, informative representations in the hippocampus (2008, unknown): “This result is consistent with data demonstrating the importance of CA3 for single trial learning (Nakazawa et al., 2003).”
Entorhinal–hippocampal neuronal circuits bridge temporally discontiguous events (2015, background): “Instead, the hippocampal CA3 region may be crucial for the formation of spatial contextual memory (Nakazawa et al. 2003; Nakashiba et al. 2008).”
Functional imaging of hippocampal place cells at cellular resolution during virtual navigation (2010, unknown): “By imaging the activity of populations of ∼ 80–100 neurons in stratum pyramidale in mice trained to navigate along a virtual linear track, place cells were identified that had characteristics very similar to spiking rate-defined place cells in both real and virtual environments 15 , 26 , 27 , 37 .”
Pattern separation, completion, and categorisation in the hippocampus and neocortex. (2016, background): “…E.T. Rolls / Neurobiology of Learning and Memory xxx (2015) xxx–xxx (as shown by the evidence from CA3-specific vs CA1-specific NMDA receptor knockouts) (Nakazawa et al., 2002, 2003, 2004; Rondi-Reig, Libbey, Eichenbaum, & Tonegawa, 2001).”
NMDA receptors, place cells and hippocampal spatial memory (2004, background): “These results showed that CA3 NMDARs are crucial for the rapid acquisition of one-trial memory of novel spatial informatio”
Using immediate-early genes to map hippocampal subregional functions. (2007, methodology): “Although these methods have been used to assess the contribution of NMDA receptors to CA3 function (Nakazawa et al. 2002, 2003; Cravens et al. 2006; Rajji et al. 2006), the behavioral consequences of targeted knockout/ knockdown of a specific IEG in CA3 has not yet been reported.”
Progressive transformation of hippocampal neuronal representations in "morphed" environments. (2005, background): “Pattern completion is expressed as the persistence of hippocampal spatial representations after removal or modification of significant subsets of the original input (O’Keefe and Conway, 1978; Muller and Kubie, 1987; Quirk et al., 1990; Nakazawa et al., 2003).”