Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

By Maik Drechsler, R. Megens, M. V. van Zandvoort, Christian Weber, Oliver Soehnlein. Circulation, 2010

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Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “…to the inflamed mouse arterial wall could also be reduced by platelet depletion or by the genetic deletion of CCR5, the receptor for the platelet-derived CCL5 (RANTES) chemokine (Drechsler et al., 2010) which is also required for atherosclerotic plaque formation (Braunersreuther et al., 2007).”
The Multifaceted Functions of Neutrophils (2013, background): “Mice genetically deficient in these molecules, and those rendered platelet deficient, have reduced atherosclerotic lesion development (190, 200).”
Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans (2013, result): “Some mouse experiments provide support for earlier involvement of polymorphonuclear leukocytes in murine atherosclerosis (Drechsler et al., 2010; Weber et al., 2008).”
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “Hyperlipidemia and also hypercholesterolemia induce neutrophilia, which is positively associated with atherosclerotic plaque burden (Drechsler et al., 2010).”