Alteration of enzyme specificity by computational loop remodeling and design
By Paul Murphy, Jill Bolduc, Jasmine L. Gallaher, Barry L. Stoddard, David Baker. 2009
134 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
In Molecular Biology
- David Baker
- Jeffrey J. Gray
- Tanja Kortemme
- I. Samish
- Po-Ssu Huang
- Brian Kuhlman
- Andrew Leaver-Fay
- Jens Meiler
Citations in the corpus
- Scientific Benchmarks for Guiding Macromolecular Energy Function Improvement (2013, background): “…Rosetta for ligand docking (Meiler & Baker, 2003), protein design (Kuhlman et al., 2003), and loop modeling (Wang, Bradley, & Baker, 2007) share a common energy function, which allowed Murphy, Bolduc, Gallaher, Stoddard, and Baker (2009) to combine them to shift an enzyme’s substrate specificity.”
- Beyond directed evolution - semi-rational protein engineering and design (2010, unknown): “[27].”
- Achievements and Challenges in Computational Protein Design. (2017, background): “In 2009 the Baker lab focused on loop remodeling to alter enzyme specificity [73].”
- Improvements to Robotics-Inspired Conformational Sampling in Rosetta (2013, background): “In particular, the demonstrated dramatic improvements in sampling conformations with subAngstrom accuracy for local protein regions make these promising strategies for use in design of new protein conformations and functions [14,15,16,17,18].”
- RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design (2011, methodology): “New backbones are built up from fragments of specified secondary structure [8,26,28].”