Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles.

By C. J. Roberts, Bryce P. Nelson, M. J. Marton, R. Stoughton, Michael R. Meyer, Holly A. Bennett, Yudong He, Hongyue Dai, W. L. Walker, Timothy R. Hughes and 3 more. Science, 2000

934 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/463fd5b5f6ba57b0a1f02770f8b57243bec117a1

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In Molecular Biology

Citations in the corpus

Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway (2011, background): “A similar global gene expression study reported the use of constitutive forms of Pkc1 and Rho1 to identify an overlapping set of CWI signalingregulated genes (Roberts et al. 2000).”
Integrated Genomic and Proteomic Analyses of Gene Expression in Mammalian Cells*S (2004, methodology): “It is similar to the error model for microarray data (13) and estimates both additive and multiplicative measurement errors in the MS relative peptide abundance measurements.”
Cell Wall Integrity Signaling in Saccharomyces cerevisiae (2005, background): “It should be noted that pheromoneinduced activation of CWI signaling is not a direct response to pheromone but rather a secondary response triggered by morphogenesis (35, 81, 276).”
Review: A current review on the regulation of dormancy in vegetative buds (2001, background): “…protein kinase (MAPK) pathways, sometimes referred to as extracellular-signal-regulated kinases (ERKs), are one of the best studied signal transduction pathways that play a central role in signaling cells to progress past the G1/S boundary (Figure 2) (Meskiene and Hirt 2000; Roberts et al. 2000).”
Quantitative Phosphoproteomics Applied to the Yeast Pheromone Signaling Pathway*S (2005, background): “regulation of the pathway, and cellular fusion (41, 46).”
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. (2007, background): “Exposure to pheromone elevates the expression of a large number of genes significantly, including those encoding proteins required for cell–cell recognition and cell–cell fusion, components of the pathway itself (positive feedback), and factors that downregulate the pathway (negative feedback) [215,”
Signal Transduction Cascades Regulating Fungal Development and Virulence (2000, background): “The FLO11 gene promoter is extremely large, ;3,000 bp, and is regulated by a complex set of transcription factors that includes Ste12/Tec1, Flo8, Sfl1, Msn1/Mss10/Phd2, and Mss11 (87, 243).”
Efficient Algorithms for Detecting Signaling Pathways in Protein Interaction Networks (2005, methodology): “(a) The main chain of the known pathway, adapted from Roberts et al. (2000).”
Gene expression profiling predicts clinical outcome of breast cancer (2002, methodology): “Fluorescence intensities of scanned images were quantified, normalized and corrected to yield the transcript abundance of a gene as an intensity ratio with respect to that of the signal of the reference poo”
Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data (2003, background): “We attribute this ability to the presence of positive and negative feedback loop”
From patterns to pathways: gene expression data analysis comes of age (2002, neutral): “Other model-based methods designed for two-color array”