Cytokine modulation of atopic dermatitis filaggrin skin expression.

By M. Howell, B. Kim, P. Gao, A. Grant, M. Boguniewicz, A. Debenedetto, L. Schneider, L. Beck, K. Barnes, D. Leung. Journal of Allergy and Clinical Immunology, 2007

938 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/46158f99d1668db4f1385fa06743784ff44653b6

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In Immunology

1. D. Leung
2. E. Brandt
3. U. Sivaprasad

Citations in the corpus

• The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and Asthma (2014, background): “We and others show that the expression of TSLP is strongly increased by keratinocytes of AD skin in IL-13 transgenic mice by immunohistochemistry and ELISA [48] and that topical application of vitamin D3 induces TSLP expression in mouse keratinocytes and triggers AD [49].”
• Atopic dermatitis: a disease of altered skin barrier and immune dysregulation (2011, background): “This is consistent with studies showing that filaggrin and other barrier protein expression in AD were downregulated through Th2 cytokine activity (33, 34).”
• Th2 Cytokines and Atopic Dermatitis (2011, background): “In addition, filaggrin expression is decreased in AD patients, even in the absence of the known mutations, and in vitro studies in keratinocytes show that the Th2 cytokines IL-4 and IL-13 can attenuate filaggrin expression [169].”