A Critical Role for Eosinophils in Allergic Airways Remodeling

By A. Humbles, C. Lloyd, Sarah J. McMillan, D. Friend, G. Xanthou, Erin E McKenna, Sorina Ghiran, N. Gerard, Channing Yu, Stuart H. Orkin and 1 more. Science, 2004

904 citations recorded by the source corpus.

Subfields: Physiology, Pulmonary and Respiratory Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/45e96fda1110c0480a08b5211303f99fc40077aa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Physiology

1. H. Hammad
2. B. Lambrecht
3. TA Wynn
4. Marc E. Rothenberg

In Pulmonary and Respiratory Medicine

1. TA Wynn
2. T. Ramalingam

In Surgery

1. H. Hammad
2. B. Lambrecht
3. TA Wynn

Citations in the corpus

• Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen (2010, methodology): “The contribution of eosinophils was studied by immunizing and challenging wt or eosinophil-deficient Gata1Dbl (Humbles et al., 2004) mice with HDM.”
• Mechanisms of fibrosis: therapeutic translation for fibrotic disease (2012, positive): “Although eosinophils have been most commonly associated with the development of pulmonary fibrosis 57 , increased numbers of eosinophils have also been linked with the activation of myofibroblasts in skin and liver fibrosis as well as idiopathic retro-peritoneal fibrosis 55,58 .”
• Anatomical profiling of G protein-coupled receptor expression (2008, positive): “Most of these receptors are known to be expressed in and/or to play a role in immune cells(Birkenbach et al., 1993;Forster et al., 1996;Forster et al., 1999;Humbles et al., 2004;Karsak et al., 2007;Kim et al., 2001;Le et al., 2001;Malone et al., 2004;Nagasawa et al., 1996;Rao et al., 1999;Soto et al”
• Eosinophils: Biological Properties and Role in Health and Disease (2008, background): “…lineage by deleting the high-affinity GATA-1 binding site on the palindromic GATA-1 promoter (Ddbl) but found that these same features of experimental asthma were unaffected by eosinophil depletion, although the cell did appear to play a critical role in airway remodeling (Humbles et al. 2004).”