Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity

By K. Okamoto, T. Nagai, A. Miyawaki, Y. Hayashi. Nature Neuroscience, 2004

872 citations recorded by the source corpus.

Subfields: Biophysics, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/45e7a12e2c54cb7e8b3684d97e3a74501c00765a

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In Biophysics

1. Richard G. M. Morris
2. R. Redondo
3. M. Sheng
4. J. Noguchi
5. Haruo Kasai

In Cellular and Molecular Neuroscience

1. R. Malenka
2. E. Nestler
3. Per Jesper Sjöström
4. S. Russo
5. M. Sheng
6. Michael Häusser
7. Arnd Roth
8. E. Rancz

Citations in the corpus

• The Addicted Synapse: Mechanisms of Synaptic and Structural Plasticity in Nucleus Accumbens (2010, background): “Stimulation protocols that induce LTD are associated with shrinkage or retraction of spines [27–29], whereas induction of LTP is associated with formation of new spines and enlargement of existing spines [27,28,30].”
• Structural and molecular remodeling of dendritic spine substructures during long-term potentiation (2014, methodology): “The amount of actin rapidly increases and, as we previously showed, it starts polymerizing into F-actin as fast as 20 s after LTP induction (Okamoto et al., 2004).”
• Dendritic excitability and synaptic plasticity. (2008, positive): “Conversely, synapse weakening may evoke the opposite decrease in spine volume (573, 879).”
• The role of the Rho GTPases in neuronal development. (2005, background): “Interestingly, a recent study has shown that tetanic stimulation causes a shift of actin equilibrium toward F-actin with a concomitant increase in spine head size in rat hippocampal neurons, while prolonged low frequency stimulation causes a shift in actin equilibrium toward G-actin, resulting in a ”
• Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. (2009, methodology): “To extend this observation, we treated control and EB3 knockdown neurons with two actin-directed drugs, latrunculin B and jasplakinolide, that are known to shift the equilibrium toward G-actin and F-actin, respectively (Okamoto et al., 2004).”
• Making memories last: the synaptic tagging and capture hypothesis (2010, methodology): “This polymerization of F-actin has been visualized via live imaging within single dendritic spine”
• Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease (2007, background): “Remodeling of actin filaments is a key determinant of spine shape (Matus, 2000) and plays a role in LTP (Okamoto et al., 2004; Zito et al., 2004).”
• Learning rules and persistence of dendritic spines (2010, background): “(Matsuzaki et al., 2004; Okamoto et al., 2004; Honkura et al., 2008) and, within the cerebral cortex, actin fibers are most concentrated in dendritic spines (Fifkova, 1985; Matus, 2000).”