Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

By M. Woodruff, R. Ramonell, Doan C. Nguyen, K. Cashman, A. Saini, N. Haddad, Ariel M. Ley, Shuya Y. Kyu, J. Howell, T. Ozturk and 23 more. Nature Immunology, 2020

698 citations recorded by the source corpus.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/45b381802a86d8d3b11eb051eac23c2a68763abb

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In Infectious Diseases

1. Alessandro Sette
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Citations in the corpus

• Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients (2021, positive): “, 2020) and B cell hyperactivation (Woodruff et al., 2020) with increased disease severity.”
• COVID-19 neutralizing antibodies predict disease severity and survival (2020, neutral): “In support of this possibility, a recent study suggests a pathogenic role of immune activation and exuberant antibody production from extrafollicular B cells in critically ill patients (Woodruff et al., 2020).”
• Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, positive): “High neutralizing antibody titers are associated with severe disease and potentially extrafollicular B cell responses (Piccoli et al., 2020; Woodruff et al., 2020), while SARS-CoV-2-specific Tfh cells have different associations depending on the study (Juno et al.”