IL-12 Family Cytokines: Immunological Playmakers
By D. Vignali, V. Kuchroo. 2012
1,233 citations recorded by the source corpus.
The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35. This feature endows these cytokines with a unique set of connections and functional interactions not shared by other cytokine families. Despite sharing many structural features and molecular partners, cytokines of the IL-12 family mediate surprisingly diverse functional effects. Here we discuss the unique and unusual structural and functional characteristics of this cytokine family. We outline how cells might interpret seemingly similar cytokine signals to give rise to the diverse functional outcomes that characterize this cytokine family. We also discuss the therapeutic implications of this complexity.
Subfields: Immunology, Oncology
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Citations in the corpus
- Non-Canonical Interleukin 23 Receptor Complex Assembly (2014, background): “Because the IL-12R 1 lacks an Ig-like domain, site II of p19 should interact with the CBM of IL-12R 1 and site III with the Ig-like domain of IL-23R (1, 13, 15).”
- SARS-CoV-2 infection: The role of cytokines in COVID-19 disease (2020, neutral): “IL-12 also induces the production of IFN-γ by T and NK cells in a positive feedback mechanism [138].”
- Structural insights into the assembly and activation of the IL‐27 signaling complex (2022, neutral): “Under some conditions, p28 and EBI3 can be secreted independently and associate with other proteins to induce differential responses (Crabe et al , 2009; Stumhofer et al , 2010; Col-lison et al , 2012; Wang et al , 2012; Garbers et al , 2013).”