Breakthrough of the year 2013. Cancer immunotherapy.

By J. Couzin-Frankel. Science, 2013

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Development and Applications of CRISPR-Cas9 for Genome Engineering (2014, background): “…analysis at multiple target sites could be a high-throughput solution for understanding binding degeneracy (Wu et al., 2014), whereas techniques for detecting and labeling double-strand breaks (Crosetto et al., 2013) will help to achieve a comprehensive map of Cas9-induced off-target indels.”
30 years of NF-κB: a blossoming of relevance to human pathobiology (2017, neutral): “Finally, as the pivotal role of the immune system in fighting malignancy has come into focus with new discoveries in immunotherapy, NF-κB inhibition is cast into a new light (Couzin-Frankel, 2013).”
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Anti-Tumor Immune Responses via Cross-Presentation of Tumor Antigen (2014, background): “Immunotherapy has recently gained mainstream recognition as a viable anticancer therapy (18, 19).”