Genipin-crosslinked chitosan hydrogels as biomedical and pharmaceutical aids

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Design and applications of interpenetrating polymer network hydrogels. A review (2014, methodology): “Recently, a new natural cross-linking agent, genipin, has been successfully used in the preparation of CS based hydrogels [28–31].”
Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review. (2018, background): “…et al., 2010; Zhang et al., 2005), formaldehyde (Singh et al., 2006), or ethylene glycol di-glycidyl ether (EGDE) (Liu et al., 2014), genipin (Mi et al., 2000; Muzzarelli, 2009b) and others (Draye, Delaey, Voorde, Bulcke, Bogdanov et al., 1998; Hennink & Nostrum, 2002; Huffman, 2012) (See Fig.”
Cross-linked soy protein as material for biodegradable films: Synthesis, characterization and biodegradation (2011, methodology): “Gen has been employed to stabilize chitosan-forming gels (Muzzarelli, 2009; Yao et al., 2004) for controlled release of drugs improving their mechanical properties and thermal stability, and decreasing their swelling in water.”