Phenotype molding of stromal cells in the lung tumor microenvironment

By D. Lambrechts, E. Wauters, B. Boeckx, S. Aibar, David Nittner, O. Burton, A. Bassez, H. Decaluwé, A. Pircher, Kathleen van den Eynde and 8 more. Nature Medicine, 2018

1,409 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/452258e315b3a2660604ada127d01306af1a3200

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. A. Mantovani
2. D. Tuveson
3. Ela Elyada

In Molecular Biology

1. Paul Robson
2. Andrea Califano
3. A. Mantovani
4. Irving L. Weissman
5. Adam J. Rubin
6. Giulia Biffi
7. Stephen R. Quake
8. D. Tuveson

In Oncology

1. A. Mantovani
2. M. Locati
3. Irving L. Weissman
4. Giulia Biffi
5. Stephen R. Quake
6. D. Tuveson
7. Ela Elyada
8. A. Sica

Citations in the corpus

• Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data (2021, neutral): “Therefore, we applied Scissor, guided by 471 TCGA-LUAD bulk samples with survival information 15 , to identify aggressive cancer cell subpopulations within 4,102 cancer cells from the same lung cancer scRNA-seq dataset 10 .”
• Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020, background): “Single-cell studies of breast and lung tumors including non-malignant tissue found a majority of tumor cells did not resemble normal counterparts, possibly indicating a distinct paradigm in those tissues (Lambrechts et al., 2018; Wagner et al., 2019).”
• TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment (2020, background): “Second, we checked the malignant cell makers’ expression distribution from the initial research, such as epithelial markers, EMT genes, if available (26).”
• Dynamic EMT: a multi‐tool for tumor progression (2021, neutral): “YAP/TAZ overexpression and activation is crucial to mediate EMT and cell plasticity in skin cancer and is sufficient to induce EMT in MCF 10 A non-cancerous mammary epithelial cells.”
• Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer (2019, background): “Consistent with the literature that activated T cells expressed high level of granzyme and immune checkpoint molecules (Lambrechts et al., 2018), we found that T-cell cytotoxicity related genes (e.”